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Name
7-methylguanosine mRNA capping [GO_0006370] Class
Alternative Names
- has_broad_synonym: 5' end capping
- has_broad_synonym: 5'-end processing
- has_exact_synonym: 5' mRNA capping
- has_exact_synonym: 5'-end mRNA processing
Classification
- 7-methylguanosine RNA capping Class
- mRNA processing Class
Description
The sequence of enzymatic reactions by which the mRNA 5' cap structure, an inverted 7-methylguanosine linked via a 5'-5' triphosphate bridge (m7G(5')ppp(5')X) to the first transcribed residue, is added to a nascent transcript. Additional methylation can occur on the ribose sugars of the first and second nucleotides adjacent to the m7G nRNA cap. These methylations are often referred to as N6,2'-O-dimethyladenosine (m6,2A) and N6,2'-O-dimethylguanosine (m6,2G), respectively.
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